{"id":1464,"date":"2019-03-18T06:42:30","date_gmt":"2019-03-18T06:42:30","guid":{"rendered":"https:\/\/www.megasaglik.com\/?p=1464"},"modified":"2019-03-18T06:42:30","modified_gmt":"2019-03-18T06:42:30","slug":"vertigo-ve-bas-donmesine-100-de-100-dogal-cozumler","status":"publish","type":"post","link":"https:\/\/megasaglik.com\/index.php\/2019\/03\/18\/vertigo-ve-bas-donmesine-100-de-100-dogal-cozumler\/","title":{"rendered":"Vertigo Ve Ba\u015f D\u00f6nmesine 100 de 100 Do\u011fal \u00c7\u00f6z\u00fcmler !"},"content":{"rendered":"<p><span style=\"color: #ff6600;\"><strong>Limon ya da ek\u015fi yemek, uzun y\u0131llardan beri ba\u015f d\u00f6nmesine kar\u015f\u0131 bir\u00e7ok k\u00fclt\u00fcrde kullan\u0131lan pratik bir tedavi y\u00f6ntemi. Nesilden nesile bir \u015fehir efsanesi gibi aktar\u0131lan ve neden i\u015fe yarad\u0131\u011f\u0131 pek bilinmeyen bu y\u00f6ntemin art\u0131k bilimsel bir a\u00e7\u0131klamas\u0131 var. 2 Mart 2018 tarihli Science dergisinde yay\u0131nlanan bu ara\u015ft\u0131rman\u0131n bulgular\u0131 ek\u015fi ile ilgili bir ara\u015ft\u0131rma yap\u0131l\u0131rken tesad\u00fcfen bulundu ama hemen belirtelim ba\u015f d\u00f6nmesi ile tat duyusu aras\u0131ndaki bu ilgin\u00e7 ba\u011flant\u0131n\u0131n t\u00fcm ayr\u0131nt\u0131lar\u0131 hen\u00fcz tam olarak ayd\u0131nlat\u0131lm\u0131\u015f de\u011fil.<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Tat duyusu ve denge hakk\u0131nda k\u0131sa bilgi: Denge, i\u00e7 kulaktaki vestib\u00fcler sistem(denge sistemi) taraf\u0131ndan ayarlan\u0131r ve g\u00fcnl\u00fck ya\u015fant\u0131m\u0131z\u0131 bu sistem sayesinde yere d\u00fc\u015fmeden s\u00fcrd\u00fcr\u00fcr\u00fcz. Ba\u015f d\u00f6nmesi ya da di\u011fer ad\u0131yla vertigo, ki\u015finin kendi bedeni ile \u00e7evre aras\u0131nda hissetti\u011fi sahte bir hareketlilik alg\u0131s\u0131d\u0131r. Vertigo, i\u00e7 kulakta bulunan \u00fc\u00e7 yar\u0131m daire \u015feklindeki yap\u0131lar i\u00e7erisindeki otokoni\/otolit ad\u0131nda biyo-minerallerin ya da di\u011fer ad\u0131yla kulak ta\u015flar\u0131n\u0131n geli\u015fig\u00fczel hareket etmesiyle ortaya \u00e7\u0131kar. Tat alma duyusu ise dilde bulunan tat resept\u00f6rleri ile al\u0131nan ba\u015fka bir v\u00fccut fonksiyonudur.<\/strong><\/span><\/p>\n<p><span style=\"color: #ff0000;\"><strong>Vertigo nedir? Neden olur? Vertigonun belirtileri ve tedavisi<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Birbirinden \u00e7ok farkl\u0131 bu iki v\u00fccut fonksiyonunun tek bir gen taraf\u0131ndan ayarland\u0131\u011f\u0131n\u0131n ortaya \u00e7\u0131kmas\u0131 olduk\u00e7a s\u00fcrpriz bir durum. A\u015fa\u011f\u0131da bu ilgin\u00e7 ara\u015ft\u0131rma ile ilgili makale bulunmaktad\u0131r. Makale, m\u00fcmk\u00fcn oldu\u011funca bilim d\u0131\u015f\u0131ndaki okuyucular\u0131n anlayaca\u011f\u0131 formatta haz\u0131rlanmaya \u00e7al\u0131\u015f\u0131ld\u0131. Konuyu daha kapsaml\u0131 anlatabilmek i\u00e7in zaman zaman konu ile ilgili yan konulara da de\u011finildi. Umar\u0131m bu yan konular\u0131 anlat\u0131rken okuyucunun dikkati da\u011f\u0131lmaz. Zira ara\u015ft\u0131rma zaten yeterince karma\u015f\u0131k ba\u011flant\u0131lar i\u00e7eriyor.<\/strong><\/span><\/p>\n<p><span style=\"color: #ff0000;\"><strong>Tat duyusu nedir<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Tat duyusu en eski ve en \u00f6nemli duyular\u0131m\u0131zdan biridir. De\u011fi\u015fik tatlar dilimizde bulunan \u00f6zelle\u015fmi\u015f tat resept\u00f6rleri taraf\u0131ndan alg\u0131lan\u0131rlar. Her ne kadar \u201eDe\u011fi\u015fik tatlar, dilimizde bulunan de\u011fi\u015fik tat resept\u00f6rleri taraf\u0131ndan alg\u0131lan\u0131r\u201c desek de tat alma konusunda as\u0131l g\u00f6revi genlerimiz \u00fcstlenir. Dilimiz, genler taraf\u0131ndan reg\u00fcle edilen tat resept\u00f6rleri sayesinde, tatl\u0131, tuzlu, ac\u0131, ek\u015fi ve umami olmak \u00fczere be\u015f temel uyaran\u0131 alg\u0131layabilir ve ayr\u0131ca \u00f6zel tat veya aromalar\u0131n ince n\u00fcanslar\u0131 ay\u0131rt edebilir.<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Tat resept\u00f6rleri ve genlerimiz aras\u0131ndaki ba\u011flant\u0131lar\u0131n karma\u015f\u0131kl\u0131\u011f\u0131 bir \u00e7ok soruyu cevaps\u0131z b\u0131raksa da, bu konuda yap\u0131lan \u00e7al\u0131\u015fmalar bizi her ge\u00e7en g\u00fcn bir ad\u0131m daha ileriye g\u00f6t\u00fcr\u00fcyor.<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>A\u015fa\u011f\u0131da bu \u00e7al\u0131\u015fmalardan bir \u00f6rnek bulunmaktad\u0131r. Ek\u015fi alg\u0131s\u0131 ilgili yap\u0131lan bu \u00e7al\u0131\u015fmay\u0131 \u015fa\u015f\u0131rt\u0131c\u0131 yapan ise ara\u015ft\u0131rman\u0131n sonunda konuyla hi\u00e7 alakal\u0131 olmayan enteresan bir ba\u011flant\u0131n\u0131n ortaya \u00e7\u0131kmas\u0131\u2026 \u015eimdi bu ilgin\u00e7 ara\u015ft\u0131rmay\u0131 dilimiz d\u00f6nd\u00fc\u011f\u00fcnce ve de gereksiz ayr\u0131nt\u0131lara girmeden anlatmaya \u00e7al\u0131\u015fal\u0131m.<\/strong><\/span><\/p>\n<p><span style=\"color: #ff0000;\"><strong>Ek\u015fi alg\u0131s\u0131<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Ek\u015fi, nas\u0131l bir tatt\u0131r, hangi gen ek\u015fi tad\u0131n\u0131 alg\u0131lamam\u0131za yard\u0131mc\u0131 olur. Dilimiz ek\u015fiyi nas\u0131l emer ve beynimiz bu tad\u0131 nas\u0131l i\u015fler. Bu sorular\u0131n baz\u0131lar\u0131n\u0131n cevab\u0131 bu makalede yer almaktad\u0131r. Baz\u0131lar\u0131n\u0131n ise hala cevap bulunamad\u0131\u011f\u0131 i\u00e7in hi\u00e7 de\u011finilmeyecek.<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Ek\u015fi nas\u0131l bir tatt\u0131r h\u00fccreye nas\u0131l girer: Ek\u015fi g\u0131dalar\u0131n pH\u2019lar\u0131 d\u00fc\u015f\u00fckt\u00fcr, yani proton(H+ ) konsantrasyonlar\u0131 y\u00fcksektir. Ba\u015fka bir ifadeyle, ek\u015fiyi ek\u015fi yapan \u015fey protonlar d\u0131r ve bu protonlar g\u0131dalar\u0131n h\u00fccreye kendili\u011finden girmesine engel olur, ancak \u00f6zel iyon kanallar\u0131n\u0131n i\u00e7erisinden ge\u00e7erek h\u00fccreye girebilirler.<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>\u00d6zel iyon kanallar\u0131: Yukar\u0131da k\u0131saca bahsedildi\u011fi gibi, ek\u015fi de di\u011fer tatlar gibi \u00f6nce dilimizdeki lezzet alg\u0131lay\u0131c\u0131 resept\u00f6rler taraf\u0131ndan alg\u0131lan\u0131r ve hemen ard\u0131ndan meydana gelen karma\u015f\u0131k biyokimyasal reaksiyonlar sonucu h\u00fccre zar\u0131nda bulunan \u00d6zel Proton Kanallar\u0131 a\u00e7\u0131l\u0131r ve ek\u015fi g\u0131dalar(ya da asidik g\u0131dalar) h\u00fccreye girer.<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Ama bu i\u015flem bu kadar basit de\u011fil. Bu biyokimyasal s\u00fcrecin bir de genler ile ilgili olan boyutu var ki, \u015fimdiye kadar bu konuda pek fazla bir \u015fey bilinmiyordu. Daha do\u011frusu sadece ek\u015finin h\u00fccre i\u00e7ine girmesine izin veren ama di\u011fer tatlar\u0131 i\u00e7eriye almayan bu \u00d6zel Proton Kanallar\u0131n\u0131n hangi gen arac\u0131l\u0131\u011f\u0131 ile a\u00e7\u0131l\u0131p kapand\u0131\u011f\u0131 bilinmiyordu.<\/strong><\/span><\/p>\n<p><span style=\"color: #ff0000;\"><strong>\u00c7\u0131lg\u0131n ke\u015fif<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>California \u00dcniversitesi taraf\u0131ndan yap\u0131lan bir ara\u015ft\u0131rma, ek\u015finin h\u00fccre i\u00e7ine al\u0131nmas\u0131 konusundaki bilgilerimizi bir ad\u0131m daha ileriye g\u00f6t\u00fcrerek \u00d6zel Proton Kanallar\u0131n\u0131n hangi gen taraf\u0131ndan reg\u00fcle edildi\u011fini anlamam\u0131z\u0131 sa\u011flad\u0131. Ara\u015ft\u0131rma sonunda d\u00f6rd\u00fcnc\u00fc kromozomda bulunan Otopetrin 1 (OTOP1) ad\u0131ndaki bir genin h\u00fccrelerde proton kanallar\u0131n\u0131n a\u00e7arak ek\u015finin h\u00fccre i\u00e7ine girmesine olanak verdi\u011fi tespit edildi.\u201d<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Ama bu ke\u015ffi s\u0131radan olmaktan \u00e7\u0131kartan, daha do\u011frusu \u015fa\u015f\u0131rt\u0131c\u0131 yapan birbiriyle ba\u011flant\u0131s\u0131 olmayan iki v\u00fccut fonksiyonunun Otopetrin 1 geni taraf\u0131ndan ayarlan\u0131yor olmas\u0131. Daha a\u00e7\u0131k bir ifadeyle s\u00f6ylemek gerekirse; Bizi eksiye kar\u015f\u0131 duyarl\u0131 yapan gen ayn\u0131 zamanda dengemizi de sa\u011fl\u0131yor.<\/strong><\/span><\/p>\n<p><span style=\"color: #ff0000;\"><strong>Otopetrin1 geninin bilinen fonksiyonu<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Otopetrin 1 geni, otopetrin ad\u0131ndaki proteini kodluyor. Bu protein, i\u00e7 kulakta yatay ve d\u00fc\u015fey dengeyi sa\u011flamakla g\u00f6revli otokoni\/otolit ad\u0131nda biyo-minerallerin olu\u015fumunu sa\u011fl\u0131yor. Otopetrin ayr\u0131ca otokoni\/otolit olu\u015fmas\u0131 i\u00e7in gerekli olan pH de\u011ferinin kararl\u0131 bir durumda kalmas\u0131n\u0131 da sa\u011fl\u0131yor.<\/strong><\/span><br \/>\n<span style=\"color: #000000;\"><strong>Ayr\u0131ca daha \u00f6nce yap\u0131lan \u00e7al\u0131\u015fmalar ile otopetrin 1 geninin sa\u011fl\u0131kl\u0131 formunun farelerde dengeyi sa\u011flad\u0131\u011f\u0131, genin genetik bir m\u00fcdahale ile i\u015flevsiz hale getirilmesi durumunda farelerin dengede kalma problemi ya\u015fad\u0131\u011f\u0131 teyid edilmi\u015fti. (1)<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Otopetrin 1 gen ailesi dil ve kulak d\u0131\u015f\u0131nda da faal olabilir<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Otopetrin-gen-ailesine ait proteinlerin \u00f6nceleri sadece i\u00e7 kulaktaki vestib\u00fcler sistemde(denge sistemide) g\u00f6rev ald\u0131\u011f\u0131, tat almayla ilgili g\u00f6revinin sadece \u00f6zel proton kanallar\u0131nda kalsiyum ak\u0131\u015f\u0131n\u0131 d\u00fczenlemek ile s\u0131n\u0131rl\u0131 oldu\u011fu d\u00fc\u015f\u00fcn\u00fcl\u00fcyordu. Ama bu \u00e7al\u0131\u015fma ile bunun b\u00f6yle olmad\u0131\u011f\u0131 aksine otopetrin proteinin \u00d6zel Proton Kanallar\u0131olu\u015fumunda bizzat rol ald\u0131\u011f\u0131n\u0131 g\u00f6sterdi.(2)<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Sonu\u00e7<\/strong><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Ara\u015ft\u0131rmac\u0131lar ek\u015fi lezzettini alg\u0131lamaktan sorumlu geni ararken kar\u015f\u0131lar\u0131na dengeyi sa\u011flayan genin \u00e7\u0131kaca\u011f\u0131n\u0131 hi\u00e7 tahmin etmiyorlard\u0131. Ancak \u015fa\u015f\u0131rt\u0131c\u0131 fonksiyonlar\u0131n ortaya \u00e7\u0131kmas\u0131 bu kadarla s\u0131n\u0131rl\u0131 kalmayabilir! Zira daha \u00f6nce yap\u0131lan baz\u0131 \u00e7al\u0131\u015fmalar, otopetrin gen familyasindaki baz\u0131 genlerin farkl\u0131 doku ve organdaki h\u00fccrelerde \u00e7e\u015fitli g\u00f6revler ald\u0131\u011f\u0131n\u0131 zaten g\u00f6stermi\u015fti. <span style=\"color: #ff0000;\">Bu y\u00fczden otopetrin 1 gen ailesinde bulunan di\u011fer genlerin dil ve kulak d\u0131\u015f\u0131nda g\u00f6zlerde, sindirim sisteminde ve cinsel organda da faal olabilirler !<\/span><\/strong><\/span><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/megasaglik.com\/wp-content\/uploads\/2019\/03\/vertigo-ve-bas-donmesine-100-de-100-dogal-cozumler.jpg\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Limon ya da ek\u015fi yemek, uzun y\u0131llardan beri ba\u015f d\u00f6nmesine kar\u015f\u0131 bir\u00e7ok k\u00fclt\u00fcrde kullan\u0131lan pratik bir tedavi y\u00f6ntemi. Nesilden nesile bir \u015fehir efsanesi gibi aktar\u0131lan ve neden i\u015fe yarad\u0131\u011f\u0131 pek bilinmeyen bu y\u00f6ntemin art\u0131k bilimsel bir a\u00e7\u0131klamas\u0131 var. 2 Mart 2018 tarihli Science dergisinde yay\u0131nlanan bu ara\u015ft\u0131rman\u0131n bulgular\u0131 ek\u015fi ile ilgili bir ara\u015ft\u0131rma yap\u0131l\u0131rken tesad\u00fcfen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1464","post","type-post","status-publish","format-standard","category-genel","czr-hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Vertigo Ve Ba\u015f D\u00f6nmesine 100 de 100 Do\u011fal \u00c7\u00f6z\u00fcmler ! - Mega Sa\u011fl\u0131k<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/megasaglik.com\/index.php\/2019\/03\/18\/vertigo-ve-bas-donmesine-100-de-100-dogal-cozumler\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vertigo Ve Ba\u015f D\u00f6nmesine 100 de 100 Do\u011fal \u00c7\u00f6z\u00fcmler ! - Mega Sa\u011fl\u0131k\" \/>\n<meta property=\"og:description\" content=\"Limon ya da ek\u015fi yemek, uzun y\u0131llardan beri ba\u015f d\u00f6nmesine kar\u015f\u0131 bir\u00e7ok k\u00fclt\u00fcrde kullan\u0131lan pratik bir tedavi y\u00f6ntemi. Nesilden nesile bir \u015fehir efsanesi gibi aktar\u0131lan ve neden i\u015fe yarad\u0131\u011f\u0131 pek bilinmeyen bu y\u00f6ntemin art\u0131k bilimsel bir a\u00e7\u0131klamas\u0131 var. 2 Mart 2018 tarihli Science dergisinde yay\u0131nlanan bu ara\u015ft\u0131rman\u0131n bulgular\u0131 ek\u015fi ile ilgili bir ara\u015ft\u0131rma yap\u0131l\u0131rken tesad\u00fcfen [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/megasaglik.com\/index.php\/2019\/03\/18\/vertigo-ve-bas-donmesine-100-de-100-dogal-cozumler\/\" \/>\n<meta property=\"og:site_name\" content=\"Mega Sa\u011fl\u0131k\" \/>\n<meta property=\"article:published_time\" content=\"2019-03-18T06:42:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/megasaglik.com\/wp-content\/uploads\/2019\/03\/vertigo-ve-bas-donmesine-100-de-100-dogal-cozumler.jpg\" \/>\n<meta name=\"author\" content=\"DrElaSoylemez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"DrElaSoylemez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/megasaglik.com\\\/index.php\\\/2019\\\/03\\\/18\\\/vertigo-ve-bas-donmesine-100-de-100-dogal-cozumler\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/megasaglik.com\\\/index.php\\\/2019\\\/03\\\/18\\\/vertigo-ve-bas-donmesine-100-de-100-dogal-cozumler\\\/\"},\"author\":{\"name\":\"DrElaSoylemez\",\"@id\":\"https:\\\/\\\/megasaglik.com\\\/#\\\/schema\\\/person\\\/e990d391e914ddf80c72371fe19e886a\"},\"headline\":\"Vertigo Ve Ba\u015f D\u00f6nmesine 100 de 100 Do\u011fal \u00c7\u00f6z\u00fcmler !\",\"datePublished\":\"2019-03-18T06:42:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/megasaglik.com\\\/index.php\\\/2019\\\/03\\\/18\\\/vertigo-ve-bas-donmesine-100-de-100-dogal-cozumler\\\/\"},\"wordCount\":1206,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/megasaglik.com\\\/index.php\\\/2019\\\/03\\\/18\\\/vertigo-ve-bas-donmesine-100-de-100-dogal-cozumler\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/megasaglik.com\\\/wp-content\\\/uploads\\\/2019\\\/03\\\/vertigo-ve-bas-donmesine-100-de-100-dogal-cozumler.jpg\",\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/megasaglik.com\\\/index.php\\\/2019\\\/03\\\/18\\\/vertigo-ve-bas-donmesine-100-de-100-dogal-cozumler\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/megasaglik.com\\\/index.php\\\/2019\\\/03\\\/18\\\/vertigo-ve-bas-donmesine-100-de-100-dogal-cozumler\\\/\",\"url\":\"https:\\\/\\\/megasaglik.com\\\/index.php\\\/2019\\\/03\\\/18\\\/vertigo-ve-bas-donmesine-100-de-100-dogal-cozumler\\\/\",\"name\":\"Vertigo Ve Ba\u015f D\u00f6nmesine 100 de 100 Do\u011fal \u00c7\u00f6z\u00fcmler ! 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